Patient Education

Risk of Liver Problems

  • JUXTAPID can cause liver problems such as increased liver enzymes or increased fat in the liver.
  • Because of the risk of liver problems, JUXTAPID should only be taken by people with homozygous familial hypercholesterolemia (HoFH).
  • Your doctor will order blood tests to check your liver before you start taking JUXTAPID, if your dose is increased, and while you are taking JUXTAPID.


Because of the risk of liver damage with JUXTAPID, the Food and Drug Administration (FDA) has required a special program called a Risk Evaluation and Mitigation Strategy (REMS).

As part of the REMS Program your prescriber will discuss the risks of JUXTAPID with you, and review the Patient Guide to the REMS Program.

After reviewing the JUXTAPID REMS Program, both you and your healthcare provider will be asked to complete a form acknowledging that you understand the risks with the use of JUXTAPID.

For additional information about the JUXTAPID REMS Program, please call 1-85-JUXTAPID (1-855-898-2743)